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Connection Between Obesity and Diabetes Discovered

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December, 2003 -- An article in this month’s issue of the Journal of Endocrinology reports a revolutionary discovery that establishes a biochemical connection between obesity and Type 2 Diabetes. Type 2 Diabetes occurs when there is either too little insulin produced by the body or the body becomes resistant to insulin resulting in an abnormal increase in blood sugar. It is estimated that approximately 16 million people suffer from Type 2 Diabetes in the United States.

This study found that diabetes in obese mice requires a hormone know as MSH, a product made by the POMC gene that occurs in both mice and humans. Obese mice without MSH hormone did not develop diabetes while administration of MSH to these mice increased resistance to insulin and directly affect blood sugar levels. The findings of this study suggest that MSH may be a factor in the development of Type 2 Diabetes. This is the first time that a link between the hormone MSH and blood sugar levels has been established and may lead to more preventative treatments for diabetes.

Source: Eleanor Roosevelt Institute (12/15/03)

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