Comparing a Single Daily Dose of Methimazole and Propylthiouracil in Graves' Treatment
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Comparing a Single Daily Dose of Methimazole and Propylthiouracil in Graves' Disease Treatment

by Mary Shomon

June 2004 -- Taiwanese researchers compared the effectiveness of a single daily dose of methimazole (MMI) versus propylthiouracil (PTU) as a treatment for Graves' hyperthyroidism.

In this study, a effects of a single daily dose of MMI and PTU were measured, based on changes to thyroid hormones and thyrotropin receptor antibodies (TRAb) levels. Total T3, Total T4 and Free T4 levels in the MMI-treated group were significantly lower than those of the PTU-treated group after 4 weeks and through the end of the study. MMI also has superior effect on reducing serum the antibody levels, versus PTU, after 8 weeks and at the end of the study. Overall, the researchers concluded that during the 12-week treatment of Graves' hyperthyroidism, a single daily dose of 15 mg MMI was much more effective in the restoration of normal thyroid function than a single daily dose of 150 mg PTU. In the doses used in this study, MMI is preferable to PTU when a once-daily regimen of antithyroid drug is considered for the treatment of Graves' hyperthyroidism.

Source: He CT, et. al. "Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves' hyperthyroidism." Clin Endocrinol (Oxf). 2004 Jun;60(6):676-81.



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